Overview
Top Medical Research Studies
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
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In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
Our study revealed that administering this innovative combination through injection significantly improved blood vessel function and decreased heart damage in mice.
The results suggest that these nattokinase-loaded nanozymes could offer a promising strategy to tackle heart attacks effectively, particularly through their antioxidant and thrombolytic properties.
Our study demonstrated that fermented milk from B. subtilis could inhibit thrombosis in mice, indicating a promising way to integrate healthy options in our diets. Notably, sensory evaluations revealed that this functional fermented milk was well-accepted, similar to traditional options.
Overall, our findings highlight the potential of B. subtilis JNFE0126-fermented milk as a delicious, healthful alternative that may help reduce cardiovascular risks.
After encapsulating NK, the nanoparticles demonstrated a successful release rate and maintained their efficacy even after storage. However, while the findings are encouraging, they suggest that NK-MNPs may not be a definitive solution but instead a promising avenue for further research into treating thrombus-related diseases.
When combined at a 1:30 molar ratio, these nanocomposites demonstrated a remarkable thrombolysis rate, effectively targeting blood clots while minimizing risk of complications. This research indicates that these nanostructures could pave the way for safer and more effective thrombolytic therapies.
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Frequently Asked Questions
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Nattokinase is an enzyme extracted from a traditional Japanese food called natto, which is made from fermented soybeans. This enzyme is thought to have potential health benefits, primarily for cardiovascular health. Nattokinase is believed to support the breakdown of fibrin in the blood, which can help improve circulation and reduce the risk of blood clot formation. As a dietary supplement, it is often marketed for its possible ability to promote healthy blood flow and cardiovascular function.
While some studies suggest that nattokinase may help reduce blood pressure and enhance overall heart health, research is still ongoing. As with any supplement, it is essential to consult with a healthcare professional before adding nattokinase to your regimen, especially if you are on blood-thinning medications or have underlying health conditions. Overall, while nattokinase might offer some intriguing health benefits, more comprehensive studies are needed to fully understand its efficacy and safety profile.
While nattokinase, an enzyme derived from fermented soybeans, has been popularized for its potential cardiovascular benefits, the scientific evidence is mixed. Nattokinase is thought to help break down fibrin, a protein involved in blood clotting, thus may support healthy circulation and reduce blood viscosity. Some studies suggest that it may help lower blood pressure and improve cholesterol levels, contributing to overall cardiovascular health. However, more extensive and rigorous clinical trials are needed to fully establish its efficacy and safety in preventing or treating cardiovascular diseases.
If you're considering nattokinase as a supplement for heart health, it's important to consult with a healthcare professional first, especially if you're on blood-thinning medications or have specific health conditions. While some users report positive results, it's essential to approach this supplement with caution and prioritize a heart-healthy lifestyle, including a balanced diet and regular exercise.
Based on user reviews, the timeline for seeing results from this supplement varies among individuals, but many users report noticing positive effects within the first week of use. For instance, one user indicated that they experienced significant improvements in overall well-being after just one week, attributing the effectiveness to the supplement's ability to dissolve fibroid clots and enhance cardiovascular health (Read Review). Another user noted normalization of their blood pressure after three weeks of consistent use (Read Review).
However, some users suggest that a longer regimen, such as two months, may yield more pronounced results. One user mentioned that after maintaining their supplement routine along with dietary adjustments for at least two months, they observed positive effects (Read Review). Therefore, while initial benefits may be felt quickly, a consistent intake over several weeks may be essential for deeper cardiovascular improvements.
Scientific research suggests that nattokinase, a fibrinolytic enzyme derived from fermented soybeans, may hold potential benefits for cardiovascular health, particularly concerning blood clot management and related conditions. Various studies indicate that nattokinase may help breakdown clots and improve vascular health. For instance, a study involving specialized magnetic nanorobots delivering nattokinase achieved an impressive clot resolution rate of 81% in mice, showcasing its targeted therapeutic potential [2]. Additionally, research highlighted the enzyme's ability to relieve inflammation and oxidative stress related to cardiovascular disease, further bolstering its role in heart health strategies [7].
However, not all studies agree on the efficacy of nattokinase for cardiovascular disease. A randomized trial with 265 participants found no significant effects on atherosclerosis progression or blood pressure after three years of nattokinase treatment, indicating that it may not yield expected benefits for those at low risk of cardiovascular events [6]. Furthermore, while it shows promise in reducing atherosclerotic symptoms, more extensive human trials are necessary to confirm its therapeutic applicability and effectiveness for cardiovascular disease management [10]. Overall, while there is encouraging data supporting the use of nattokinase, further investigation is warranted to fully establish its role in cardiovascular health.
Users report a variety of improvements in symptoms after using the supplement, particularly in relation to cardiovascular health. Many have noted that they experience enhanced overall well-being shortly after starting the regimen. For instance, one user mentioned feeling significant improvements in their Long Covid symptoms after just a week of use, attributing these changes to the product's ability to work through issues like fibroid clots (Read Review). Another individual experienced normalization of their blood pressure within three weeks, underscoring the supplement's potential benefits for cardiovascular function (Read Review).
Moreover, consistent use over a longer duration, such as two months, has led some users to report a more pronounced impact on their health. This included enhanced mobility, reduced blood pressure, and overall improvements in cardiovascular support (Read Review). Users have also indicated that the combination of nattokinase and serrapeptase within the supplement plays a crucial role in breaking down harmful proteins and supporting blood circulation, which many found particularly beneficial during recovery from respiratory diseases and cardiovascular conditions (Read Review). It is important to note that individual results can vary, and consulting a healthcare provider before starting any new supplement is advisable.
Users report positive experiences when combining this supplement with other components in their health routines for cardiovascular disease management. Many individuals have found that incorporating the enzymes Nattokinase and Serrapeptase enhances their effectiveness, often citing improvements in blood circulation and blood pressure regulation (Read Review). One reviewer mentioned that adding another capsule per day led to a noticeable "tightening up" of their body and improved cardiovascular metrics like lowering blood pressure within a few weeks (Read Review).
Moreover, users appreciate the synergy of these enzymes in supporting overall cardiovascular health while providing anti-inflammatory benefits, which could potentially aid in the recovery from various ailments (Read Review). Some have also experienced effectiveness in addressing chronic conditions by modifying their diets alongside the supplement regimen, indicating that such combinations can yield significant health benefits. Overall, the general consensus among users emphasizes the advantageous effects of integrating this supplement with a holistic health approach, although it is always recommended to consult with a healthcare provider for personalized guidance (Read Review).
Based on user reviews, the right dose for Nattokinase in treating cardiovascular disease seems to vary among individuals, but there are some commonalities. One user reported taking one capsule daily and then increasing to two capsules which resulted in feeling "lighter" and normalizing their blood pressure within three weeks (Read Review). Another review points to the effectiveness of the product when taken as part of a routine, indicating that maintaining a regimen for at least two months was beneficial for cardiovascular health and reducing inflammation (Read Review).
Additionally, users advise that taking Nattokinase—often in combination with Serrapeptase—before meals or after a few hours can maximize its effects (Read Review). Many users agree on the positive impact of the supplement on blood circulation and cardiovascular health, but they also emphasize that individual responses can vary. Therefore, consulting a healthcare provider before starting this or any supplement is considered wise (Read Review).
In a study involving thrombotic mice, these nattokinase-loaded nanorobots showed an impressive vasculature recanalization rate of 81%. This dual approach of mechanical damage and heat-triggered nattokinase release represents a significant advancement in noninvasive thrombolytic therapy.
Our research demonstrated that NK not only alleviated inflammation and oxidative stress in mouse models but also improved kidney health affected by inflammation.
NK showed remarkable effects by inhibiting key inflammatory responses and reducing harmful proteins related to clot formation. While its promise is evident in early research, further studies are necessary to fully understand its benefits for human cardiovascular health.
Our findings revealed that nattokinase had no significant effect on subclinical atherosclerosis progression, blood pressure, or other laboratory measures. This indicates that nattokinase may not provide the anticipated cardiovascular benefits in healthy individuals at low risk for heart disease.
While both treatments improved lipid profiles, the statin group saw more significant cholesterol reductions. Notably, nattokinase increased HDL levels, showing promise as a potential alternative to statins in managing atherosclerosis, though its effects appear unrelated to lipid changes.
References
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Gao R, Zhang W, Chen X, Shen J, Qin Y, et al. Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis. ACS Nano. 2024;18:29492. doi:10.1021/acsnano.4c04331
- Zhang X, Tong Y, Wang J, Lyu X, Yang R. Screening of a Bacillus subtilis strain producing both nattokinase and milk-clotting enzyme and its application in fermented milk with thrombolytic activity. J Dairy Sci. 2021;104:9437. doi:10.3168/jds.2020-19756
- Gallelli G, Di Mizio G, Palleria C, Siniscalchi A, Rubino P, et al. Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases. Nutrients. 2021;13. doi:10.3390/nu13062031
- Liu S, Zhu J, Liu C, Li J, Li Z, et al. Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis. Pharmazie. 2021;76:145. doi:10.1691/ph.2021.0155
- Hodis HN, Mack WJ, Meiselman HJ, Kalra V, Liebman H, et al. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021;78:339. doi:10.3233/CH-211147
- Wu H, Wang Y, Zhang Y, Xu F, Chen J, et al. Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol. 2020;32:101500. doi:10.1016/j.redox.2020.101500
- Pan X, Liang P, Teng L, Ren Y, Peng J, et al. Study on molecular mechanisms of nattokinase in pharmacological action based on label-free liquid chromatography-tandem mass spectrometry. Food Sci Nutr. 2019;7:3185. doi:10.1002/fsn3.1157
- Wu C, Gao C, Lü S, Xu X, Wen N, et al. Construction of polylysine dendrimer nanocomposites carrying nattokinase and their application in thrombolysis. J Biomed Mater Res A. 2018;106:440. doi:10.1002/jbm.a.36232
- Ren NN, Chen HJ, Li Y, Mcgowan GW, Lin YG. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017;97:2038. doi:10.3760/cma.j.issn.0376-2491.2017.26.005
